NSC 71795 (hydrochloride)
Ellipticine (hydrochloride)
CAS: 5081-48-1
Molecular Formula: C17H15ClN2
NSC 71795 (hydrochloride) - Names and Identifiers
| Name | Ellipticine (hydrochloride) |
| Synonyms | NSC 71795 (hydrochloride) Ellipticine (hydrochloride) Ellipticine hydrochloride(NSC 71795 hydrochloride) |
| CAS | 5081-48-1 |
NSC 71795 (hydrochloride) - Physico-chemical Properties
| Molecular Formula | C17H15ClN2 |
| Molar Mass | 282.77 |
| Solubility | DMSO: 5.8 mg/mL |
| Storage Condition | Inert atmosphere,Store in freezer, under -20°C |
| In vitro study | Ellipticine (NSC 71795) is a potent antineoplastic agent exhibiting the multimodal mechanism of its action. The mechanisms of Ellipticine (NSC 71795) antitumor, mutagenic and cytotoxic activities are suggested to be intercalation into DNA and inhibition of DNA topoisomerase II activity. Another mode of Ellipticine (NSC 71795) action is the formation of covalent DNA adducts mediated by its oxidation with cytochromes P450 (CYP) and peroxidases. Ellipticine (NSC 71795) can also act as an inhibitor or inducer of biotransformation enzymes, thereby modulating its own metabolism leading to its genotoxic and pharmacological effects. Treatment of cells with Ellipticine (NSC 71795) results in inhibition of cell growth and proliferation. This effect is associated with formation of two covalent Ellipticine (NSC 71795)-derived DNA adducts. |
| In vivo study | Ellipticine (NSC 71795) treatment results in ellipticine-derived DNA adduct generation in several healthy organs (liver, kidney, lung, spleen, breast, heart and brain) and in DNA of mammary adenocarcinoma. The levels of Ellipticine (NSC 71795)-derived DNA adducts generated in these adenocarcinomas are almost 2-fold higher than in normal healthy mammary tissue. The induced expression of cytochrome b 5 protein in liver of rats treated with Ellipticine (NSC 71795) suggests that cytochrome b 5 may modulate the CYP-mediated bioactivation and detoxification of Ellipticine (NSC 71795). |
NSC 71795 (hydrochloride) - Preparation solution concentration reference
| 1mg | 5mg | 10mg | |
|---|---|---|---|
| 1 mM | 3.536 ml | 17.682 ml | 35.365 ml |
| 5 mM | 0.707 ml | 3.536 ml | 7.073 ml |
| 10 mM | 0.354 ml | 1.768 ml | 3.536 ml |
| 5 mM | 0.071 ml | 0.354 ml | 0.707 ml |
Last Update：2024-01-02 23:10:35
Supplier List
Spot supply
Product Name: Ellipticine (hydrochloride) Visit Supplier Webpage Request for quotationCAS: 5081-48-1
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
Wechat: 18301782025
Spot supply
Product Name: Ellipticine (hydrochloride) Visit Supplier Webpage Request for quotationCAS: 5081-48-1
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
Wechat: 18301782025
View History